Research advances in zebrafish as a model of liver cancer / 临床肝胆病杂志

ABSTRACT

The incidence rate of liver cancer tends to increase in recent years, and the molecular and pathogenic mechanisms of liver cancer should be further investigated to guarantee health. As an important model organism, zebrafish have highly conserved genes and grow fast. The early embryo of zebrafish is transparent, which helps with the real-time observation of the development process. Zebrafish are similar to humans in the composition, function, and signaling pathways of hepatocytes, as well as response to injury. In modern biological studies, zebrafish have been wildly used as the model of liver diseases. This article summarizes the research advances in the application of zebrafish as the model of liver cancer, and points out that the techniques for establishing the zebrafish model of liver cancer have become mature. With the constant development of experimental techniques, great achievements will be achieved in the field of liver cancer.