Advances in studies of ileal apical sodium-dependent bile acid transporter / 药学学报
Acta Pharmaceutica Sinica
; (12): 189-197, 2017.
Article
de Zh
| WPRIM
| ID: wpr-779578
Bibliothèque responsable:
WPRO
ABSTRACT
Bile acids play critical roles in the regulation of metabolism and absorption of lipids. The ileal apical sodium-dependent bile acid transporter (ASBT) located at the enterocyte brush border is responsible for the reuptake of bile acids and the maintenance of bile acid homeostasis. Recently, a number of investigations have been made concerning the regulation and control of ASBT and the relationship between ASBT and intestinal inflammation, tumorigenesis, diabetes mellitus and hyperlipemia, which suggests ASBT as a potential therapeutic target of these diseases. In this review, advances in the study of above-mentioned issues were summarized.
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1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2017
Type:
Article