A Single Intraperitoneal Injection of Endotoxin Changes Glial Cells in Rats as Revealed by Positron Emission Tomography Using ¹¹CPK11195 / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
; : 224-228, 2018.
Article
Dans En
| WPRIM
| ID: wpr-786988
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE:
Intracranial administration of lipopolysaccharide (LPS) is known to elicit a rapid innate immune response, activate glial cells in the brain, and induce depression-like behavior. However, no study has focused on the changes in glial cells induced by intraperitoneal injection of LPS in vivo.METHODS:
Ten adult male Fischer F344 rats underwent [¹¹C]PK11195 PET before and 2 days after intraperitoneal injection of LPS to evaluate the changes in glial cells. The difference in standardized uptake values (SUV) of [¹¹C]PK11195 between before and after injection was determined.RESULTS:
There was a cluster of brain regions that showed significant reductions in SUV. This cluster included the bilateral striata and bilateral frontal regions, especially the somatosensory areas.CONCLUSIONS:
Changes in activity of glial cells induced by the intraperitoneal injection of LPS were detected in vivo by [¹¹C]PK11195 PET. Intraperitoneal injection of LPS is known to induce depression, and further studies with [¹¹C]PK11195 PET would clarify the relationships between neuroinflammation and depression.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Rats de lignée F344
/
Encéphale
/
Lipopolysaccharides
/
Névroglie
/
Tomographie par émission de positons
/
Dépression
/
Électrons
/
Immunité innée
/
Injections péritoneales
Limites du sujet:
Animals
/
Humans
/
Male
langue:
En
Texte intégral:
Korean Journal of Nuclear Medicine
Année:
2018
Type:
Article