Analysis of PD-L1 expression in salivary duct carcinoma with its efficacy as a tumor marker / 대한두경부종양학회지
Korean Journal of Head and Neck Oncology
; (2): 13-20, 2019.
Article
Dans Ko
| WPRIM
| ID: wpr-787522
Responsable en Bibliothèque :
WPRO
ABSTRACT
BACKGROUND/OBJECTIVES:
Despite multiple approaches of treatments for salivary duct carcinoma, there has been a need for more successful treatment methods because of its poor prognosis. Treatment options like immunotherapy using new technologies have been attempted. Based on recent study results indicating that targeting programmed death receptors are effective in treating various cancers, this study aimed to identify the frequency of PD-L1 expression and its impact on survival rate in salivary duct carcinoma.MATERIALS #SPCHAR_X0026;METHODS:
We studied 33 patients with salivary gland cancer who were available for histologic specimens. We examined the expression of PD-L1 in the tissues and analyzed the association with the survival rate and the association with various clinical parameters.RESULTS:
According to this study and review of similar studies, we discovered that the expression of PD-L1 in salivary duct carcinoma was lower than other types of cancers. The impact of PD-L1 on survival rate also showed inconsistency in salivary duct carcinoma.CONCLUSION:
Immunotherapy by PD-1/PD-L1 checkpoint blockade in salivary duct carcinoma needs further evaluation for clinical application.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Tumeurs des glandes salivaires
/
Taux de survie
/
Conduits salivaires
/
Récepteurs à domaine de mort
/
Immunothérapie
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Head and Neck Oncology
Année:
2019
Type:
Article