The association between mode of action and adverse outcome pathway and its application in risk assessment / 中华预防医学杂志
Chinese Journal of Preventive Medicine
; (12): 219-223, 2020.
Article
de Zh
| WPRIM
| ID: wpr-787744
Bibliothèque responsable:
WPRO
ABSTRACT
Risk assessment is a necessary technical means to protect human health and environmental safety. Traditional risk assessment based on toxicity data obtained from animal experiments was difficult to meet the need for risk assessment for a large number of chemicals due to the low throughput, long cycle, high cost and uncertainty of extrapolation to human exposure dose. The proposed risk assessment frameworks, the model of action (MOA) and the adverse outcome pathway (AOP), pointed the way for us to develop new and efficient evaluation methods. In this review, the basic concepts and contents of MOA and AOP, as well as the relationship between them, were introduced. Taking acrylamide (AA) as an example, this review briefly described the application of MOA/AOP framework in chemical risk assessment, so as to provide theoretical guidance for better application of MOA/AOP framework in chemical risk assessment.
Texte intégral:
1
Indice:
WPRIM
Type d'étude:
Etiology_studies
/
Risk_factors_studies
langue:
Zh
Texte intégral:
Chinese Journal of Preventive Medicine
Année:
2020
Type:
Article