Agomelatine: Antidepressant with a New Mechanism of Action / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 283-292, 2009.
Article
Dans Ko
| WPRIM
| ID: wpr-78815
Responsable en Bibliothèque :
WPRO
ABSTRACT
Currently available pharmacotherapies for depression still have a limited antidepressant efficacy with a delayed onset of several weeks, and still cause side effects. These unmet needs represent important reasons to continue to search for novel treatment options. A disorganization of circadian rhythms has been suggested to play an important role in the pathophysiology of major depression. Agomelatine is a new agent with a unique pharmacological profile. Agomelatine is both an agonist of melatonergic MT(1) and MT(2) receptors and a serotonergic 5-HT(2C) receptor antagonist. Many clinical trials have demonstrated the superior efficacy of agomelatine in comparison with placebo in the treatment major depressive disorder at the standard dose of 25 mg/day, with the possibility of increasing doses to 50 mg/day in those patients with insufficient improvement. Agomelatine was even effective in severely depressed patients. The safety and tolerability of agomelatine was comparable to placebo. It does not induce the side effects including serotonin syndrome and sexual dysfunction or discontinuation syndrome typical to other therapies, such as selective serotonin reuptake inhibitors. These properties give agomelatine a definite clinical advantage in the treatment of depression.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Rythme circadien
/
Inbiteurs sélectifs de la recapture de la sérotonine
/
Syndrome sérotoninergique
/
Récepteur de la sérotonine de type 5-HT2C
/
Dépression
/
Trouble dépressif majeur
/
Imidazoles
/
Acétamides
/
Composés nitrés
Type d'étude:
Clinical_trials
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Korean Journal of Psychopharmacology
Année:
2009
Type:
Article