GATA1-positive Acute Megakaryoblastic Leukemia in a 6.9-year-old Patient with Down Syndrome: What is the Prognosis? / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 66-70, 2013.
Article
de En
| WPRIM
| ID: wpr-788479
Bibliothèque responsable:
WPRO
ABSTRACT
We describe a very rare case of 6.9-year-old boy with Down syndrome (DS) and a prior history of transient myeloproliferative disorder. He was diagnosed with acute megakaryoblastic leukemia and found to have a novel GATA1 gene mutation, as well as a complex karyotype without recurrent acute myeloid leukemia (AML) aberrations. The patient achieved an early bone marrow response to chemotherapy. However, relapse occurred during treatment, 9 months after the initial diagnosis. Although GATA1 mutations are closely associated with DS-AML, we speculate that factors other than the presence of the GATA1 mutation can affect the overall outcome in older pediatric patients.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Récidive
/
Moelle osseuse
/
Leucémie aigüe myéloïde
/
Leucémie aigüe mégacaryoblastique
/
Syndrome de Down
/
Caryotype
/
Syndromes myéloprolifératifs
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Clinical Pediatric Hematology-Oncology
Année:
2013
Type:
Article