Gamma Knife Radiosurgery for Cancer Metastasized to the Ocular Choroid
Journal of Korean Neurosurgical Society
; : 60-65, 2018.
Article
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| WPRIM
| ID: wpr-788654
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE:
Choroidal metastases (CMs) are the most common intraocular tumor. Management is mainly radiation therapy with goals of pain control and visual improvement. However, many radiation-related complications are reported. Since gamma knife radiosurgery (GKS) for CM was first reported in 1995, few cases have been reported. We report 7 cases of CMs treated with GKS.METHODS:
From April 2011 to November 2014, 7 patients with CM underwent GKS. Their median age at treatment was 64 years (range, 51–71 years). Four males and three females were treated. Lung cancer was the most common primary pathology, followed by renal cell carcinoma and stomach cancer. Four patients had multiple cerebral lesions and were treated simultaneously for choroidal lesions. The median marginal dose of 20 Gy (range, 15–25 Gy) was administered at the 50% isodose line.RESULTS:
Median follow-up period after GKS was 8 months (range, 2–38.3 months). Four patients expired due to underlying malignancy progression. Except for two patients who were not followed with magnetic resonance image after GKS, all patients showed size reduction in the treated lesions, but a new choroidal lesion appeared in one patient and one recurred. Six of seven patients reported subjectively improved visual symptoms. Visual acuity improved in 2 patients, and 2 were stable upon objective examination. One patient showed no improvement in visual acuity, but ocular pain was relieved; another patient showed improved vision and tumor remission, but visual deterioration recurred.CONCLUSION:
GKS was shown to be safe and effective and should be considered for CM treatment.
Texte intégral:
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Indice:
WPRIM
Sujet Principal:
Orbite
/
Anatomopathologie
/
Tumeurs de l'estomac
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Néphrocarcinome
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Acuité visuelle
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Études de suivi
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Choroïde
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Radiochirurgie
/
Tumeurs du poumon
/
Métastase tumorale
Type d'étude:
Observational_studies
/
Prognostic_studies
Limites du sujet:
Female
/
Humans
/
Male
langue:
En
Texte intégral:
Journal of Korean Neurosurgical Society
Année:
2018
Type:
Article