Therapeutic effect of single Chinese medicine Bidens pilosa grain on hyperlipidemia and its influence on serum levels of MMP‐9 and TIMP‐1 / 心血管康复医学杂志
Chinese Journal of cardiovascular Rehabilitation Medicine
; (6): 661-665, 2019.
Article
Dans Zh
| WPRIM
| ID: wpr-790151
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective:
To explore therapeutic effect of single Chinese medicine Bidens pilosa grain on hyperlipidemia and its influence on serum levels of matrix metalloproteinase‐9 (MMP‐9) and tissue inhibitor of metalloproteinases‐1 (TIMP‐1).Methods:
A total of 186 hyperlipidemia patients treated in our hospital from Jan 2014 to Jun 2017 were randomly divid‐ed into Bidens pilosa group (n=94 ,received Bidens pilosa grain based on routine treatment ) and Xuezhikang group (n=92 ,received Xuezhikang based on routine treatment ).Both groups were treated for two months .Serum levels of total cho‐lesterol (TC) , triglyceride (TG ) ,low density lipoprptein cholesterol (LDL‐ C) , high density lipoprptein cholesterol (HDL‐C) ,MMP‐9 and TIMP‐1 before and after treatment ,and total effective rate were observed and compared between two groups.Results:
Compared with before treatment ,after treatment ,there were significant reductions in serum levels of TC ,TG ,LDL‐C and MMP‐9 [ Bidens pilosa group (24.46 ± 4.92) μg/L vs.(20.53 ± 2.69) μg/L ,Xuezhikang group(23.40 ± 2.57) μg/L vs.(19.98 ± 2.02) μg/L] ,and significant rise in serum levels of HDL‐C [ Bidens pilosa group(1.28 ± 0.45) mmol/L vs.(1.54 ± 0.52) mmol/L , Xuezhikang group (1.28 ± 0.45) mmol/L vs.(1.55 ± 0.52) mmol/L] and TIMP‐1 [ Bidens pilosa group (4.67 ± 1.26) μg/L vs.(6.02 ± 2.24) μg/L ,Xuezhikang group(4.63 ± 1.30) μg/L vs.(6.01 ± 2.31) μg/L] in two groups , P=0.001 all.After treatment ,there were no significant difference in serum levels of TC ,TG ,LDL‐C ,HDL‐C ,MMP‐9 and TIMP‐1 and total effective rate between two groups , P>0.05 all.Conclusion:
Bidens pilosa can significantly improve serum lipid level ,reduce serum level of MMP‐9 and increase serum level of TIMP‐1 in hyperlipidemia patients .It's no significant difference compared with Xuezhikang .
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langue:
Zh
Texte intégral:
Chinese Journal of cardiovascular Rehabilitation Medicine
Année:
2019
Type:
Article