Advances on receptor tyrosine kinase inhibitors taking c-Met as anti-tumor target / 中国药科大学学报
Journal of China Pharmaceutical University
; (6): 16-27, 2015.
Article
de Zh
| WPRIM
| ID: wpr-811897
Bibliothèque responsable:
WPRO
ABSTRACT
@#c-Met receptor tyrosine kinase plays an important role in signaling pathways including cell proliferation, metabolism as well as tumorigenic growth, migration and angiogenesis. c-Met has emerged as an attractive target for cancer therapy. Moreover, the interactive cross-talk between c-Met signaling and several other signaling pathways underlies a key effect for resistance of anti-cancer drugs. Thus, multi-target inhibitors become a new approach to cancer therapy. This paper introduces the c-Met signaling pathway and the resistance of kinase inhibitors caused by the cross-talk between c-Met and other membrane receptors and then will reviews the progress of single-target and multi-target c-Met inhibitors.
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WPRIM
langue:
Zh
Texte intégral:
Journal of China Pharmaceutical University
Année:
2015
Type:
Article