Estrogen receptor gene polymorphisms and HBV-induced liver cirrhosis / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 379-382, 2006.
Article
de Zh
| WPRIM
| ID: wpr-813693
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To investigate the relationship between estrogen receptor (ER) gene polymorphisms and HBV-induced cirrhosis.@*METHODS@#Xba I and Pvu II polymorphisms of ER gene were analyzed in 98 patients with HBV-induced cirrhosis, 72 patients with chronic hepatitis B, and 84 healthy controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.@*RESULTS@#The frequencies of Pp genotype and P allele of ER gene in patients with HBV-induced cirrhosis were higher than those in patients with chronic hepatitis B and controls, while the frequencies of pp genotype and p allele of ER gene in patients with HBV-induced cirrhosis were lower than those in patients with chronic hepatitis B and controls (P 0.05).@*CONCLUSION@#Pp genotype and P allele might be the susceptibility gene for HBV-induced cirrhosis while pp genotype and p allele might be the protective gene.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Polymorphisme génétique
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Polymorphisme de restriction
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Récepteurs des oestrogènes
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Réaction de polymérisation en chaîne
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Hépatite B chronique
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Allèles
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Génétique
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Génotype
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Cirrhose du foie
Limites du sujet:
Adolescent
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Adult
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Aged
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Female
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Humans
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Male
langue:
Zh
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2006
Type:
Article