Effects of compound malt pills on expressions of ERα and ERβ in ovaries of rats with letrozole-induced polycystic ovarian syndrome / 中南大学学报(医学版)
Journal of Central South University(Medical Sciences)
; (12): 134-142, 2016.
Article
Dans Zh
| WPRIM
| ID: wpr-815062
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE@#To explore the effect of compound malt pills (CMP) on polycystic ovarian syndrome (PCOS) rat model induced by letrozole and the underlying mechanisms.
@*METHODS@#To establish a PCOS rat model, 48 female SD rats aged 6 weeks were randomly divided into 6 groups (n=8) A normal group, a model control group, a positive control group, a low-dose CMP group, a middle-dose CMP group, and a high-dose CMP group. Rats were treated for 21 days after the PCOS model was successfully established. Ovarian morphology changes were observed, and the expressions of ERα and ERβ was examined by immunohistochemistry, Western blot and RT-PCR, respectively.
@*RESULTS@#Compared with the normal group, the number of follicular cystic dilatation in the model control group was increased and the granulosa cells were decreased. After the treatment, the number of follicular cystic dilatation was reduced compared with the model control group, but the primordial follicles, corpus luteum and granulosa cells were increased. The expressions of ERα and ERβ in the model control group were significantly decreased (P<0.01), which were increased in the intervention groups (P<0.05 or P<0.01).
@*CONCLUSION@#CMP may play a role in the treatment of PCOS by regulating the expressions of ERα and ERβ.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
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Syndrome des ovaires polykystiques
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Triazoles
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Médicaments issus de plantes chinoises
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Rat Sprague-Dawley
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Corps jaune
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Récepteur alpha des oestrogènes
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Récepteur bêta des oestrogènes
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Modèles animaux de maladie humaine
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Létrozole
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Journal of Central South University(Medical Sciences)
Année:
2016
Type:
Article