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Expression of perforin and granzyme-B in peripheral blood lymphocyte in patients with prostate cancer and the clinical significance / 中南大学学报(医学版)
Article Dans Zh | WPRIM | ID: wpr-815162
Responsable en Bibliothèque : WPRO
ABSTRACT
OBJECTIVE@#To explore the expression of perforin and granzyme-B in peripheral blood lymphocyte (PBL) in patients with prostate cancer (PCa) and the clinical significance.@*METHODS@#The expressions of perforin and granzyme-B in PBL were detected by fluorescence quantitative reverse transcription polymerase chain reaction. The results of perforin and granzyme-B expression were compared among patients with PCa (n=60), patients with BPH (benign prostatic hyperplasia, n=40) and healthy controls (n=20).@*RESULTS@#Th e expressions of perforin and granzyme-B in patients with PCa were significantly lower than that in patients with BPH or that in the healthy controls (P<0.05), respectively. Furthermore, in PCa patients with low pathological grade, the expressions of perforin and granzyme-B in PBL was statistically higher than that in patients with high pathological grade (P<0.05). The expressions of perforin and granzyme-B in PCa patients at high clinical stage was statistically lower than that in PCa patients at low clinical stage (P<0.05).@*CONCLUSION@#The results of this study suggest that development and progression of PCa might be associated with poor immune status of patients.
Sujets)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Hyperplasie de la prostate / Tumeurs de la prostate / Lymphocytes / Études cas-témoins / Allergie et immunologie / Granzymes / Perforine / Métabolisme Type d'étude: Observational_studies / Risk_factors_studies Limites du sujet: Humans / Male langue: Zh Texte intégral: Journal of Central South University(Medical Sciences) Année: 2015 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Hyperplasie de la prostate / Tumeurs de la prostate / Lymphocytes / Études cas-témoins / Allergie et immunologie / Granzymes / Perforine / Métabolisme Type d'étude: Observational_studies / Risk_factors_studies Limites du sujet: Humans / Male langue: Zh Texte intégral: Journal of Central South University(Medical Sciences) Année: 2015 Type: Article