Early protection of exposed intra-abdominal organs in open abdomen therapy / 医学研究生学报

ABSTRACT

Open abdomen therapy (OA) is a breakthrough in treating abdominal trauma and infections. Enterorrhexis and entero-atmospheric fistula are both severe complications of OA and impact the therapeutic effect of OA seriously. To solve this problem, the pathophysiology of the OA wound formation and development, and the early protection measures of the OA wound are studied. Many biomaterials were developed, including autologous fibrin glue, electrospinning nanofiber membrane and hydrogel, to realize the target of early protection of the OA wound through hemostasis, anti-infection, antioxidation, and proliferation promoting.