Protection effect of Xuanfudaizhetang on reflux esophagitis in rats
Asian Pacific Journal of Tropical Medicine
; (12): 267-270, 2014.
Article
Dans En
| WPRIM
| ID: wpr-819691
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE@#To study protection effect of Xuanfudaizhetang on reflux esophagitis in rats.@*METHODS@#A total of 50 Wistar rats were randomly divided into groups A, B, C, D and E with 10 in each. Reflux esophagitis model in rats was established by incomplete helicobacter seam+lower esophagus sphincterotomy. All rats were divided into 5 groups group A as control group, group B as model group, group C with saline lavage treatment, group D with motilium treatment, group E with Xuanfudaizhetang lavage treatment. Recovery of esophageal, gastric mucosa and pH changes of rats were compared between groups.@*RESULTS@#Weight gain in group D and E was significantly higher in than group C; the esophageal mucosa grades and esophagus tissue pathological morphology grades of group D and E were higher than that of group B and C with significant difference between groups (P<0.05); pH of lower esophageal mucosa in group D and E increased significantly than that in the group B and C (P<0.05), and the distal mucosal pH dropped significantly in the group B and C (P<0.05).@*CONCLUSIONS@#Xuanfudaizhetang can obviously improve the pH of lower esophageal mucosa in rats with reflux esophagitis, decrease pH value of gastric mucosal, thus improve esophageal mucosa pathological conditions to achieve therapeutic effect on reflux esophagitis.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Anatomopathologie
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Pharmacologie
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Agents gastro-intestinaux
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Médicaments issus de plantes chinoises
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Prise de poids
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Oesophagite peptique
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Rat Wistar
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Agents protecteurs
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Traitement médicamenteux
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Oesophage
Limites du sujet:
Animals
langue:
En
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2014
Type:
Article