Predicted essential proteins of Plasmodium falciparum for potential drug targets
Asian Pacific Journal of Tropical Medicine
; (12): 352-354, 2012.
Article
Dans En
| WPRIM
| ID: wpr-819769
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE@#To identify novel drug targets for treatment of Plasmodium falciparum.@*METHODS@#Local BLASTP were used to find the proteins non-homologous to human essential proteins as novel drug targets. Functional domains of novel drug targets were identified by InterPro and Pfam, 3D structures of potential drug targets were predicated by the SWISS-MODEL workspace. Ligands and ligand-binding sites of the proteins were searched by Ef-seek.@*RESULTS@#Three essential proteins were identified that might be considered as potential drug targets. AAN37254.1 belonged to 1-deoxy-D-xylulose 5-phosphate reductoisomerase, CAD50499.1 belonged to chorismate synthase, CAD51220.1 belonged to FAD binging 3 family, but the function of CAD51220.1 was unknown. The 3D structures, ligands and ligand-binding sites of AAN37254.1 and CAD50499.1 were successfully predicated.@*CONCLUSIONS@#Two of these potential drug targets are key enzymes in 2-C-methyl-d-erythritol 4-phosphate pathway and shikimate pathway, which are absent in humans, so these two essential proteins are good potential drug targets. The function and 3D structures of CAD50499.1 is still unknown, it still need further study.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Plasmodium falciparum
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Protéines
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Chimie
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Paludisme à Plasmodium falciparum
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Similitude structurale de protéines
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Utilisations thérapeutiques
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Traitement médicamenteux
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Ligands
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Conformation moléculaire
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Antipaludiques
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Asian Pacific Journal of Tropical Medicine
Année:
2012
Type:
Article