Your browser doesn't support javascript.
loading
Clinical Characteristics of 219 Patients with Primary Gastrointestinal Non-Hodgkin's Lymphoma / 中国实验血液学杂志
Article de Zh | WPRIM | ID: wpr-827197
Bibliothèque responsable: WPRO
ABSTRACT
OBJECTIVE@#To analyze the clinical and pathological characteristics of primary gastrointestinal non-Hodgkin's lymphoma (PGI-NHL) patients, and to explore the factors affecting the patients' survival and prognosis.@*METHODS@#The clinical data of 219 patients with PGI-NHL diagnosed in our hospital from March 2009 to April 2016 was collected and retrospectively analyzed. Survival analysis was performed by using the Kaplan-Meier method. Log-rank test was used for comparison among the groups, and Cox regression was used for multivariate analysis.@*RESULTS@#Among the 219 patients with PGI-NHL, 126 patients were males and 93 patients were females. 182 patients were IPI 0 to 2 and 37 patients were IPI 3 to 5. There were 205 cases (93.6%) of B cell phenotype and 14 cases (6.4%) of T cell phenotype. 140 patients (63.9%) were patients with primary gastric NHL, including 85 DLBCL and 19 MALT. 79 cases (36.1%) were patients with primary intestinal NHL, including 46 DLBCL, 4 MALT, 7 FL, 3 MCL and 4 Burkitt lymphoma. 23 cases were HP positive and received anti-HP therapy. 57 cases and 32 cases received surgery and chemotherapy respectively. 84 cases received combination treatment of surgery and chemotherapy and 11 cases received combination treatment of radiotherapy and chemotherapy. Overall survival (OS) of indolent B-cell non-Hodgkin's lymphoma was longer than that of invasive B-cell non-Hodgkin's lymphoma, which shows better prognose. Kaplan-Meier analysis showed that there was no difference between progression-free survival (PFS) and OS in the patients with different origin sites, age and sex. There was no significant difference in PFS between B-cell and T-cell-derived patients, whereas OS of B-cell-derived PGI-NHL patients was longer than that of T-cell-derived PGI-NHL patients. The OS and PFS of patients with IPI 0-2 were longer than those of patients with IPI 3-5. According to Lugano and Ann Arbor staging systems, there was no difference in prognosis of patients between phase I/II and III/IV. The prognosis of patients treated with surgery alone was worse than that of patients treated with combination therapy, and the prognosis of patients with surgery combined with chemotherapy was not significantly different from that of patients with chemotherapy alone.@*CONCLUSION@#B-cell phenotype, indolent and low IPI score lymphoma indicate better prognosis, while that of different origin site, sex and age shows no different in prognosis. Surgery is used only for emergency case or pathological materials, and these patients should be treated with chemotherapy-based combined treatment.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Lymphome malin non hodgkinien / Protocoles de polychimiothérapie antinéoplasique / Analyse de survie / Études rétrospectives / Survie sans rechute / Tumeurs gastro-intestinales / Stadification tumorale Type d'étude: Observational_studies / Prognostic_studies Limites du sujet: Female / Humans / Male langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2020 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Lymphome malin non hodgkinien / Protocoles de polychimiothérapie antinéoplasique / Analyse de survie / Études rétrospectives / Survie sans rechute / Tumeurs gastro-intestinales / Stadification tumorale Type d'étude: Observational_studies / Prognostic_studies Limites du sujet: Female / Humans / Male langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2020 Type: Article