Natural products as potent inhibitors of hypoxia-inducible factor-1α in cancer therapy / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 696-703, 2020.
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Dans En
| WPRIM
| ID: wpr-827787
Responsable en Bibliothèque :
WPRO
ABSTRACT
Hypoxia is a prominent feature of tumors. Hypoxia-inducible factor-1α (HIF-1α), a major subunit of HIF-1, is overexpressed in hypoxic tumor tissues and activates the transcription of many oncogenes. Accumulating evidence has demonstrated that HIF-1α promotes tumor angiogenesis, metastasis, metabolism, and immune evasion. Natural products are an important source of antitumor drugs and numerous studies have highlighted the crucial role of these agents in modulating HIF-1α. The present review describes the role of HIF-1α in tumor progression, summarizes natural products used as HIF-1α inhibitors, and discusses the potential of developing natural products as HIF-1α inhibitors for the treatment of cancer.
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WPRIM
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2020
Type:
Article