Characterization of inthomycin biosynthetic gene cluster revealing new insights into carboxamide formation / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 677-683, 2020.
Article
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| ID: wpr-827789
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ABSTRACT
Inthomycins are polyketide antibiotics which contain a terminal carboxamide group and a triene chain. Inthomycin B (1) and its two new analogues 2 and 3 were isolated from the crude extract of Streptomyces pactum L8. Identification of the gene cluster for inthomycin biosynthesis as well as the N-labeled glycine incorporation into inthomycins are described. Combined with the gene deletion of the rare P450 domain in the NRPS module, a formation mechanism of carboxamide moiety in inthomycins was proposed via an oxidative release of the assembly chain assisted by the P450 domain.
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WPRIM
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2020
Type:
Article