Structural characteristics of pharmacodynamical components in genuine Moutan Cortex / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 3351-3359, 2020.
Article
Dans Zh
| WPRIM
| ID: wpr-828437
Responsable en Bibliothèque :
WPRO
ABSTRACT
Guided by the theory of "component structure", we analyzed the structural characteristics of pharmacodynamical components in genuine Moutan Cortex. The compositions of organic small molecules were determined by high performance liquid chromatography(HPLC) for 20 batches of genuine Moutan Cortex and 12 batches of non-genuine Moutan Cortex. By means of similarity analysis, clustering analysis(CA), principal component analysis(PCA) and orthogonal partial least-squares discriminant analysis(OPLS-DA), the elements in structural characteristics of the pharmacodynamical components were extracted as follows terpene glycosides components(oxidized paeoniflorin, paeoniflorin,galloyl paeoniflorin, benzoyloxy paeoniflorinand benzoyl paeoniflorin), tannin components(1,3,6-tri-O-galloside acyl glucose, pentagalloyl glucose), and phenolic acid components(methyl gallate, paeonol). The contents and quantity ratios of terpene glycoside component, tannin component and phenolic acid components in genuine Moutan Cortex were determined as 14.1, 12.5, 21.7 mg·g~(-1), 1.00∶0.89∶1.54. The contents and quantity ratios of the oxidized paeoniflorin, paeoniflorin and benzoylpaeoniflorin in the terpene glycoside components were characteristic and determined as 2.05, 7.05, 3.30 mg·g~(-1), 1.00∶3.44∶1.61. The unique structural characteristics of genuine Moutan Cortex provide scientific basis for the formulation of quality standards.
Texte intégral:
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Indice:
WPRIM
Sujet Principal:
Médicaments issus de plantes chinoises
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Chromatographie en phase liquide à haute performance
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Paeonia
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Analyse en composantes principales
langue:
Zh
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2020
Type:
Article