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Efficacy of Haploidentical Hematopoietic Stem Cell Transplantation in Treatment of Intermediate Risk Acute Myeloid Leukemia with Negative for FLT3-ITD, NPM1 or Biallelic CEBPA Mutation / 中国实验血液学杂志
Article de Zh | WPRIM | ID: wpr-829051
Bibliothèque responsable: WPRO
ABSTRACT
OBJECTIVE@#To compare the efficacy of haploidentical hematopoietic stem cell transplantation (hi-HSCT) HLA-matched sibling donor hematopoietic stem cell transplantation (MSD-HSCT) and post-remission chemotherapy (PR-CT) in treatment of intermediate risk acute myeloid leukemia with negative for FLT3-ITD, NPM1 or biallelic CEBPA mutation.@*METHODS@#The clinical data of patients with intermediate risk NPM1/non-CEBPA/FLT3-ITD AML from October 2009 to May 2016 were retrospectively analyzed.@*RESULTS@#The overall survival rate of the patients treated with PR-CT, MSD-HSCT or hi-HSCT was 63.7%, 71.7%, 75.5%, respectively (P<0.05); the disease-free survival (DFS) rate was 52.8%, 67.1%, 71.3% respectively (P<0.001); the cumulative incidence of relapse was 24.7%, 16.9%, 14.4% respectively (P<0.05); the non-relapse mortality was 26.2%, 17.3%, 14.4% reapectively (P>0.05). The analysis of transplantation, related adverse events showed that II-IV grade of aGVHD in the MSD-HSCT group and hi-HSCT group was 48.9% and 45.6% respectively (P>0.05); the extensive cGVHD event was 21.6% and 8.8% (P<0.05) respectively.@*CONCLUSION@#The efficiency of hi-HSCT and MSD-HSCT is superior to that of PR-CT for treatment of patients with intermediate risk NPM1/non-CEBPA/FLT3-ITD AML after CR1, there is no statistically significant difference in the efficiency of consolidatorg treatment and the transplantation-related mortality between hi-HSCT and MSD-HSCT.
Sujet(s)
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Protéines nucléaires / Leucémie aigüe myéloïde / Études rétrospectives / Transplantation de cellules souches hématopoïétiques / Protéines liant les séquences stimulatrices de type CCAAT / Tyrosine kinase-3 de type fms / Mutation Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies Limites du sujet: Humans langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2020 Type: Article
Texte intégral: 1 Indice: WPRIM Sujet Principal: Pronostic / Protéines nucléaires / Leucémie aigüe myéloïde / Études rétrospectives / Transplantation de cellules souches hématopoïétiques / Protéines liant les séquences stimulatrices de type CCAAT / Tyrosine kinase-3 de type fms / Mutation Type d'étude: Etiology_studies / Observational_studies / Prognostic_studies Limites du sujet: Humans langue: Zh Texte intégral: Journal of Experimental Hematology Année: 2020 Type: Article