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Association between high fatty liver index and development of colorectal cancer: a nationwide cohort study with 21,592,374 Korean
Article | WPRIM | ID: wpr-831889
Bibliothèque responsable: WPRO
ABSTRACT
Background/Aims@#In Korea, the incidence of colorectal cancer (CRC) and nonalcoholic fatty liver disease (NAFLD) has increased due to a westernized lifestyle. This study investigated whether a high fatty liver index that reflects NAFLD correlates with CRC. @*Methods@#Data from the National Health Insurance Corporation 2009 to 2012 were analyzed. NAFLD disease was defined as a fatty liver index > 60 in the absence of alcohol consumption of ≥ 30 g/day. @*Results@#NAFLD was identified in 2,543,649 (11.8%) of 21,592,374 participants. CRC was identified in 19,785 (0.8%) of participants with NAFLD (fatty liver index ≥ 60) and in 80,871 (0.6%) participants without NAFLD (fatty liver index < 30). Multivariate logistic regression analysis demonstrated an independent association between NAFLD and CRC after adjusting for other confounders (hazard ratio, 1.13; odds ratio, 1.12 to 1.15). In subgroup analyses, fatty liver index ≥ 60 was associated with CRC regardless of body mass index, but the association was more prominent in persons with a normal index. NAFLD, in the absence of diabetes, hypertension, or dyslipidemia, was more highly associated with CRC than when one or more of these conditions are present. @*Conclusions@#CRC should be considered as a possibility in patients with fatty liver index ≥ 60, even in the absence of obesity or other metabolic syndromes.
Texte intégral: 1 Indice: WPRIM Type d'étude: Etiology_studies / Observational_studies Texte intégral: The Korean Journal of Internal Medicine Année: 2020 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Etiology_studies / Observational_studies Texte intégral: The Korean Journal of Internal Medicine Année: 2020 Type: Article