Worsening of Psychotic Symptoms in Patients with Chronic Schizophrenia after Switching to or Combining Aripiprazole and Aripiprazole Monthly (Abilify Maintena) / 신경정신의학

ABSTRACT

Objectives@#Aripiprazole is an antipsychotic that functions as a partial agonist in hypodopaminergic states and a dopamine antagonist in hyperdopaminergic states. @*Methods@#This paper reports a series of five clinical cases of worsening psychotic symptoms in schizophrenic patients related to the initiation of aripiprazole, oral and injection, as combination therapy. @*Results@#In all five cases, the switching of aripiprazole improved the psychotic symptoms. @*Conclusion@#Even with the suggestive relationship between aripiprazole therapy and the worsening of psychotic symptoms, further research is needed.