Coexistence of Malaria and Thalassemia in Malaria Endemic Areas of Thailand
The Korean Journal of Parasitology
; : 265-270, 2015.
Article
Dans En
| WPRIM
| ID: wpr-83623
Responsable en Bibliothèque :
WPRO
ABSTRACT
Hemoglobinopathy and malaria are commonly found worldwide particularly in malaria endemic areas. Thalassemia, the alteration of globin chain synthesis, has been reported to confer resistance against malaria. The prevalence of thalassemia was investigated in 101 malaria patients with Plasmodium falciparum and Plasmodium vivax along the Thai-Myanmar border to examine protective effect of thalassemia against severe malaria. Hemoglobin typing was performed using low pressure liquid chromatography (LPLC) and alpha-thalassemia was confirmed by multiplex PCR. Five types of thalassemia were observed in malaria patients. The 2 major types of thalassemia were Hb E (18.8%) and alpha-thalassemia-2 (11.9%). There was no association between thalassemia hemoglobinopathy and malaria parasitemia, an indicator of malaria disease severity. Thalassemia had no significant association with P. vivax infection, but the parasitemia in patients with coexistence of P. vivax and thalassemia was about 2-3 times lower than those with coexistence of P. falciparum and thalassemia and malaria without thalassemia. Furthermore, the parasitemia of P. vivax in patients with coexistence of Hb E showed lower value than coexistence with other types of thalassemia and malaria without coexistence. Parasitemia, hemoglobin, and hematocrit values in patients with coexistence of thalassemia other than Hb E were significantly lower than those without coexistence of thalassemia. Furthermore, parasitemia with coexistence of Hb E were 2 times lower than those with coexistence of thalassemia other than Hb E. In conclusion, the results may, at least in part, support the protective effect of thalassemia on the development of hyperparasitemia and severe anemia in malaria patients.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Plasmodium falciparum
/
Plasmodium vivax
/
Thaïlande
/
Thalassémie
/
Hémoglobines
/
Paludisme à Plasmodium vivax
/
Paludisme à Plasmodium falciparum
Limites du sujet:
Female
/
Humans
/
Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
The Korean Journal of Parasitology
Année:
2015
Type:
Article