Effectiveness of premedication and rapid desensitization in hypersensitivity to L-asparaginase
Allergy, Asthma & Respiratory Disease
; : 288-293, 2015.
Article
de Ko
| WPRIM
| ID: wpr-83769
Bibliothèque responsable:
WPRO
ABSTRACT
PURPOSE: L-asparaginase is a crucial chemotherapeutic agent for the treatment of acute lymphoblastic leukemia. However, hypersensitivity to L-asparaginase is common which limits its clinical use. METHODS: We performed 44 cases of premedication and 3 cases of desensitization in 16 patients with hypersensitivity to L-asparaginase. RESULTS: With premedication, 33 cases completed L-asparaginase injection with no hypersensitivity reactions. Eleven cases showed mild hypersensitivity reactions, such as urticaria. Desensitization was performed in 3 cases: in 2 cases, desensitization was successful, and in 1 case the medication was switched to Erwinia asparaginase. CONCLUSION: Premedication and desensitization appear to be useful in helping patients receive desired doses of L-asparaginase in pediatric patients with acute lymphoblastic leukemia.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Prémédication
/
Asparaginase
/
Urticaire
/
Désensibilisation immunologique
/
Hypersensibilité médicamenteuse
/
Erwinia
/
Leucémie-lymphome lymphoblastique à précurseurs B et T
/
Hypersensibilité
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Allergy, Asthma & Respiratory Disease
Année:
2015
Type:
Article