A new green room temperature ionic liquid catalyzes synthesis of monastrol and its derivatives through Biginelli reaction / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 1019-1022, 2011.
Article
Dans Zh
| WPRIM
| ID: wpr-839930
Responsable en Bibliothèque :
WPRO
ABSTRACT
Objective To explore an easily-controllable, environmentally-friendly method for synthesizing monastrol and its derivatives. Methods Monastrol and its derivatives were synthesized using (substituted) benzaldehyde, ethyl acetoacetate and thiourea (or urea) as the material through a Biginelli reaction catalyzed by green room temperature ionic liquid 1-buty-3- methylimidazolium-L-camphorsulfonate under microwave irradiation without solvent. Results The green room temperature ionic liquid 1-buty-3-methylimidazolium-L-camphorsulfonate catalyzed Biginelli reaction in obtaining the title compound under microwave irradiation without solvent. The process was easy to operate, time saving and environmentally-friendly. Conclusion Microwave-accelerated solvent-free Biginelli reaction using green room temperature ionic liquid 1-buty-3-methylimidazolium-L- camphorsulfonate as catalyst is a convenient and environmentally-friendly method for synthesizing monastrol and its derivatives.
Texte intégral:
1
Indice:
WPRIM
langue:
Zh
Texte intégral:
Academic Journal of Second Military Medical University
Année:
2011
Type:
Article