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Study on Methodology Re-evaluation for Systematic Review/Meta-analysis of Antidepressants in the Treatment of Post-stroke Depression / 中国药房
China Pharmacy ; (12): 3036-3041, 2020.
Article de Zh | WPRIM | ID: wpr-843085
Bibliothèque responsable: WPRO
ABSTRACT
OBJECTIVE: To re-evaluate t he methodology quality of published systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression. METHODS :Retrieved from Cochrane Library ,PubMed,Embase, SinoMed,CNKI,Wanfang database ,VIP,CBM and other databases ,systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression were collected during the inception to Dec. 2019. After literature screening and data extraction , methodology quality of included literatures were evaluated by using the AMSTAR scale. RESULTS :A total of 33 systematic reviews/Meta-analysis were included ,involving 523 RCTs and 41 020 patients. Average score of AMSTAR methodological quality evaluation was 6.76. Citalopram ,duloxetine and paroxetine were effective for the therapy of post-stroke depression ,but the conclusions about the effectiveness among antide-pressants were not consistents. The ADR incidence of Paroxetine was low. It was not clear that sertraline and citalopram may improve the neurological function of patients. CONCLUSIONS :The methodological quality of systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression is medium ,and the conclusions about the effectiveness of antidepressants ,improvement of daily life ability and the recovery of neurological function are still controversial.
Mots clés
Texte intégral: 1 Indice: WPRIM Type d'étude: Systematic_reviews langue: Zh Texte intégral: China Pharmacy Année: 2020 Type: Article
Texte intégral: 1 Indice: WPRIM Type d'étude: Systematic_reviews langue: Zh Texte intégral: China Pharmacy Année: 2020 Type: Article