Neutralizing monoclonal antibodies against the West Nile virus: research advances / 国际药学研究杂志

ABSTRACT

West Nile virus(WNV)is a member of the Flavivirus genus, which can cause zoonotic diseases or even death. With the gradual globalization of WNV infection epidemic, there exists an input risk in China. Now there are no approved vaccines and drugs for the prevention and treatment of human infection with WNV. Hence, research and de- velopment of drugs against WNV is necessary. WNV envelope(E)protein, the main antigen of neutralizing antibody, is involving in the infection of the target cells by the virus. The E protein contains three structural domains(D, DⅡ and DIII). This review briefly describes the recent advances in neutralizing antibodies targeting these three domains.