Spatiotemporal regulation of fibroblast growth factor signal blocking for endoderm formation in Xenopus laevis
Experimental & Molecular Medicine
; : 550-557, 2008.
Article
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| ID: wpr-84647
Responsable en Bibliothèque :
WPRO
ABSTRACT
We have previously shown that the inhibition of fibroblast growth factor (FGF) signaling induced endodermal gene expression in the animal cap and caused the expansion of the endodermal mass in Xenopus embryos. However, we still do not know whether or not the alteration of FGF signaling controls embryonic cell fate, or when FGF signal blocking is required for endoderm formation in Xenopus. Here, we show that FGF signal blocking in embryonic cells causes their descendants to move into the endodermal region and to express endodermal genes. It is also interesting that blocking FGF signaling between fertilization and embryonic stage 10.5 promotes endoderm formation, but persistent FGF signaling blocking after stage 10.5 restricts endoderm formation and differentiation.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pyrroles
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Xenopus laevis
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Transduction du signal
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Récepteur facteur croissance fibroblaste
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Hybridation in situ
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Régulation de l'expression des gènes au cours du développement
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RT-PCR
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Protéines de Xénope
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Endoderme
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Facteurs de croissance fibroblastique
Limites du sujet:
Animals
langue:
En
Texte intégral:
Experimental & Molecular Medicine
Année:
2008
Type:
Article