Chemical constituents of alcohol extract of Mori Fructus / 中草药

ABSTRACT

Objective: To investigate the chemical constituents of alcohol extract of Mori Fructus. Methods: The chemical constituents were isolated and identified by chromatography on silica gel, Sephadex LH-20, ODS, and RP-HPLC. Their structures were elucidated on the basis of physicochemical properties and spectral analyses. Results: Twelve compounds were isolated from the alcohol extract of Mori Fructus, and identified as mullignanoside (1), (7R,8S)-4,7,9,9’-tetrahydroxy-3,3’-dimethoxy-8-O-4’-neolignan- 9’-O-β-D-glucopyranoside (2), 2-phenylethyl-β-D-glucopyranoside (3), 1’-O-phenethyl-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside (4), benzyl-O-β-D-glucopyranoside (5), ergosterol peroxide (6), (24R)-6β-hydroxy-24-ethyl-cholest-4-en-3-one (7), (22E)-5α,8α- epidioxy-24-methyl-cholesta-6,9(11),22-trien-3β-ol (8), trans-(S)-(+)-abscisic acid (9), cis-(S)-(+)-abscisic acid (10), (S)-(+)-1- methyl-abscisic-6-acid (11) and phaseic acid (12). Conclusion: Compound 1 is a new compound named mullignanoside, and compounds 2, 7-12 are isolated from this plant for the first time.