New advance of in vitro and in vivo studies on lumbar intervertebrai disc biomechanics / 中国组织工程研究

ABSTRACT

BACKGROUND: Clinical systems caused by degenerative disc disease are one of the largest health worldwide problems. Changes of biomechanics of lumbar disc play important difference in the development of degenerative disc disease OBJECTIVE: To briefly describe the anatomical and histological features of lumbar Intervertebral discs, and to review the research methods and progress in lumbar intervertebral disc biomechanics in recent years. METHODS: A computer-based online retrieval of CNKI, Wanfang, VIP, PubMed, Elsevier and Web of Science databases was conducted with the keywords of “biomechanics, intervertebral disc, lumbar spine, finite element analysis, imaging, MRI, BFIS, DSXS” in Chinese and English, respectively. The articles were firstly screened by reading the title and abstract, and 67 eligible articles were included for result analysis after excluding irrelevant articles. RESULTS AND CONCLUSION: (1) The research on lumbar disc biomechanics is mainly divided into in vitro research and in vivo research. (2) In vitro studies include animal specimens, human cadavers and finite element analysis. The design of in vitro experiment is flexible and maneuverable, but it is separated from human physiological environment and the mechanical properties of materials are different. After long-term verification, the applicability of the experiment in human body is screened out. (3) In vivo studies mainly record the changes of the force shape of disc movement in vivo in real time through imaging methods, which is real and reliable. However, limited by the development of imaging technology, it needs to be used reasonably. The new biplanar fluorescent imaging system and dynamic stereo-radiography system have unique advantages in this field, which attracted much attention.