Preparation of the surface patterned polyacrylamide-acrylic hydrogel / 中国组织工程研究

ABSTRACT

BACKGROUND: Polyacrylamide hydrogels have good biocompatibility, but their mechanical properties are poor, which affect their application in the field of biomaterials. OBJECTIVE: To prepare the polyacrylamide-acrylic hydrogels with a particular size by micromolding graphical imprinting. METHODS: Polyacrylamide-acrylic hydrogel was prepared by sequentially mixing different volumes of polyacrylamide solution, acrylic acid and ammonium persulfate solution into an orifice plate containing a micromolded patterned seal. Group A: Polyacrylamide solution 1.4 mL, acrylic acid 0.1 mL; group B: Polyacrylamide solution 1.3 mL, acrylic acid 0.2 mL; group C: Polyacrylamide solution 1.2 mL, acrylic acid 0.3 mL; group D: Polyacrylamide solution 1.1 mL, acrylic acid 0.4 mL; group E: Polyacrylamide solution 1.0 mL, acrylic acid 0.5 mL; group F: Polyacrylamide solution 0.9 mL, acrylic acid 0.6 mL. Six groups of ammonium persulfate solution were all 50 µL. The patterned structure of the hydrogel was observed under a light microscope. The mechanical properties of the hydrogel were examined by an electronic universal testing machine. RESULTS AND CONCLUSION: Light microscope showed that the stripes on the surface of each group of hydrogels were clearly visible. The addition of acrylic acid effectively improved the mechanical properties of hydrogels. As the proportion of acrylic acid increased, the mechanical properties of hydrogels gradually increased. These results suggest that polyacrylic acid/acrylamide hydrogel has good mechanical properties and is expected to have good application prospects in the field of tissue engineering damage repair.