Advances in cell proliferation and apoptosis signal pathway and therapies of polycystic kidney disease / 解放军医学杂志
Medical Journal of Chinese People's Liberation Army
; (12): 949-954, 2016.
Article
Dans Zh
| WPRIM
| ID: wpr-850098
Responsable en Bibliothèque :
WPRO
ABSTRACT
Polycystic kidney disease (PKD) is one of the monogenic inherited diseases. In PKD, excessive cell proliferation and fluid secretion, and disruption of the mechanisms controlling tubular diameter may all lead to cyst formation. Current evidence has demonstrated that intracellular calcium ion and cAMP imbalance drive both abnormal cell proliferation and apoptosis signal pathway. The present paper summarized the evidence implicating calcium ion and cAMP as central players in the signaling pathway of cell proliferation and apoptosis in PKD, and considered the potential therapeutic approaches targeted to slow cyst growth in PKD.
Texte intégral:
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WPRIM
langue:
Zh
Texte intégral:
Medical Journal of Chinese People's Liberation Army
Année:
2016
Type:
Article