Explore correlation between quality of standard decoction and marker component amygdalin of decoction slices of blazing Armeniacae Semen Amarum / 中草药

ABSTRACT

Objective To explore the relevance between the quality of standard decoction and the marker component amygdalin of decoction slices of blazing Armeniacae Semen Amarum (BASA) by mathematical model. Methods The BASA standard decoction was prepared, and three linear regression models of the amygdalin content and dry extract rate, the content of amygdalin in standard decoction and decoction slices, and the transfer rate in standard decoction and the content of amygdalin in decoction slices were established by using Design-Expert 8.0.6 software, respectively. Results The dry extract rate of BASA was 8.97%-12.12%; The content of amygdalin in standard decoction was 21.74%-30.32%; And the transfer rate of amygdalin was 70.39%-90.54%. The R2 values of three linear regression models were all greater than 0.8. The P values of each partial regression coefficient were less than 0.05, which indicated that the three models were significant. Then the accuracy of three linear regression models was verified. The relative deviation between the predicted and measured values was less than 10%, and the average relative deviation was not greater than 5%. Conclusion The models established in this study could predict the quality of standard decoction prepared from different BASA, and provide a certain reference value for the establishment of standard decoction quality standard.