Alkaloids from stems of Nauclea officinalis / 中草药

ABSTRACT

Objective: To study the alkaloids from the stems of Nauclea officinalis. Methods: The chemical constituents were separated and purified by silica gel, ODS column chromatography, and preparative HPLC. Their structures were determined by UV, MS, and NMR spectroscopic analyses. Results: Thirteen compounds were isolated from the stems of N. officinalis, the structures were identified as 3-R-3,4-dihydroangustoline (1), blumenol A (2), naucleofficine D (3), 1,2,3,4-tetrahydro-β-carboline (4), 3-S-3,4-dihydroangustoline (5), latifoliamide D (6), latifoliamide B (7), angustoline (8), 3,14-dihydroangustine (9), 3,14,18,19- tetrahydroangustine (10), 6'-acetyl-strictosamide (11), vincosamide (12), and strictosamide (13). Conclusion: Compounds 2 and 4 are obtained from the plants of Nauclea L. for the first time. Compounds 2, 4, 6, 7, 9, and 10 are obtained from N. officinalis for the first time.