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Studies on grinding degree of Cordyceps sinensis based on in vitro dissolusion and pharmacodynamics of anti-hepatic fibrosis / 中草药
Zhongcaoyao ; Zhongcaoyao;(24): 2823-2827, 2013.
Article de Zh | WPRIM | ID: wpr-855082
Bibliothèque responsable: WPRO
ABSTRACT
Objective: To study the optimum particle size of Cordyceps sinensis for liver fibrosis in combination with in vitro dissolution experiment from serum pharmacology. Methods: To prepare the powder samples with different grinding degrees, Cordyceps sinensis was crushed through 100-, 150-, 200-, and 300-mesh sieves. The in vitro dissolution of adenosine was measured at different time points. Meanwhile, the powder sample was ig administered to rats, and pharmacodynamic approach was adopted to study the inhibition of medicated serum on HSC-T6 proliferation. Results: The accumulative in vitro dissolution of C. sinensis by 200-300 meshes was higher than that of other meshes. Medicated serum could significantly inhibit HSC-T6 cell proliferation. The AUC of HSC-T6 inhibition kinetics of medicated serum crushed to 200-300 meshes was significantly higher than that in other groups. Conclusion: The in vitro dissolution and pharmacodynamic method could be used for the study on different particle sizes of C. sinensis for anti-hepatic fibrosis, and 200-300 meshes are the optimal particle size.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Zhongcaoyao Année: 2013 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Zhongcaoyao Année: 2013 Type: Article