Purification technology for decarburization fluid of Reduning Injection by polysulfone ultrafiltration membrane / 中草药

ABSTRACT

Objective: To investigate the ultrafiltration effect of polysulfone hollow fiber ultrafiltration membrane and polysulfone plate ultrafiltration membrane with relative molecular weight by different cut-off on the decarburization fluid of Reduning Injection. Methods: The transfer rates of chlorogenic acid and geniposide, fingerprint similarity, and removal of bacterial endotoxin, protein, oxalate, and resin before and after ultrafiltration were used as inspect indicators to optimize the purification technology for the decarburization fluid of Reduning Injection. Results: The obvious effect of polysulfone hollow fiber ultrafiltration membrane with the relative molecular weight 10000 on oxalate and resin in the decarburization fluid of Reduning Injection was observed. Bacterial endotoxin (100%) in the decarburization fluid of Reduning Injection was removed by the polysulfone plate ultrafiltration membrane with the relative molecular weight 5000. Conclusion: The stability and the preparation safety of Reduning Injection could be ensured by the two stage combination of the ultrafiltration membrane technology.