Research progress in relationships between mTOR signaling pathway and drug addiction in central nervous system / 中国药理学与毒理学杂志

ABSTRACT

Drug addiction is a chronic recurrent brain disease. Repeated drug exposure may lead to neuroadaptive changes in the brain loop, and obsessive-compulsive drug seeking behaviors. In vivo, the signal transduction cascade amplification pathway mediates the remodeling of the reward loop of the central nervous system. Related studies have shown that the mammalian target of rapamycin (mTOR) signaling pathway is directly related to drug addiction, inducing neural adaptation and reward effects. Therefore, the research progress in mTOR signaling pathway and relationships between drug addiction were reviewed, and the prospects of research on the molecular mechanism of drug addiction were discussed.