Specialized proresolving mediators in immune regulation of severe infection / 中国小儿急救医学

ABSTRACT

Specialized pro-resolving mediators(SPMs)are lipid mediators derived from essential fatty acids, which have anti-inflammatory/pro-resolution effects.SPMs mainly include lipoxin, resolvin, protectin, and maresin.Different SPMs can bind to different receptors[formyl peptide receptor 2(ALX/FPR2), G protein-coupled receptor 32(DRV1/GPR32), G protein-coupled receptor 18(DRV2/GPR18), or chemokine-like receptor 1(ERV1/CMKLR1)], through nuclear factor-κB, signal transducer and activator of transcription or mitogen-activated protein kinase signal pathways to proresolve inflammation by limiting neutrophil migration and infiltration, regulating inflammatory cytokine expression, and enhancing macrophage phagocytosis.SPMs have potential clinical value in severe disease severity, prognosis prediction and clinical intervention efficacy.This article focused on the role and potential clinical value of SPMs in immune-inflammatory response to severe infection.