A new dimeric benzylisoquinoline alkaloid from Corydalis yanhusuo / 药学学报
Acta Pharmaceutica Sinica
; (12): 553-556, 2021.
Article
de Zh
| WPRIM
| ID: wpr-873782
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WPRO
ABSTRACT
(±)-Bicoryanhunine B (1), a new dimeric benzylisoquinoline alkaloid was isolated from the dried tubers of Corydalis yanhusuo by various chromatographic methods, including silica gel, Sephadex LH-20, reverse phase C18, and semi-preparative HPLC. Its structure was determined by spectroscopic methods, including UV, IR, ESI-MS, HR-ESI-MS and 1D/2D NMR. (±)-Bicoryanhunine B (1) was a moderate PD-1/PD-L1 interaction inhibitor with an IC50 value of 7.80 ± 0.49 μmol·L-1. In addition, 1 exhibited potent inhibitory activities against LPS-induced NO production in RAW 264.7 macrophages with an IC50 value of 4.83 ± 2.21 μmol·L-1.
Texte intégral:
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2021
Type:
Article