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Cell Autonomous Circadian Systems and Their Relation to Inflammation
Article de En | WPRIM | ID: wpr-874303
Bibliothèque responsable: WPRO
ABSTRACT
All living beings on earth have an important mechanism of 24-h periodicity, which controls their physiology, metabolism, and behavior. In humans, 24-h periodicity is regulated by the superchiasmatic nucleus (SCN) through external and environmental cues.Peripheral organs demonstrate circadian rhythms and circadian clock functions, and these are also observed in cultured cell lines.Every cell contains a CLOCK: BMAL1 loop for the generation of circadian rhythms. In this review, we focused on cell autonomous circadian rhythms in immune cells, the inflammatory diseases caused by disruption of circadian rhythms in hormones, and the role of clock genes in inflammatory diseases.
Texte intégral: 1 Indice: WPRIM langue: En Texte intégral: Biomolecules & Therapeutics Année: 2021 Type: Article
Texte intégral: 1 Indice: WPRIM langue: En Texte intégral: Biomolecules & Therapeutics Année: 2021 Type: Article