Effect of pretreatment of acupuncture on learning-memory ability and related protein of NLRP3 inflammasome in hippocampus in Alzheimer's disease like rats / 中国针灸
Zhongguo zhenjiu
; (12): 1323-1327, 2020.
Article
de Zh
| WPRIM
| ID: wpr-877535
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To observe the effect of pretreatment of acupuncture on the expression of nucleotide-binding oligomerization domain-like receptor 3(NLRP3), Caspase-1, interleukin1β(IL-1β) and the number of activated microglia (MG) in the hippocampus in Alzheimer's disease (AD) like rats, so as to explore the mechanism of pretreatment of acupuncture in preventing and treating AD.@*METHODS@#A total of 36 SD rats were randomly divided into a blank group, a model group and an electroacupuncture (EA) group, 12 rats in each group. The AD like rat model was established by 8-week continuous intraperitoneal injection of D-galactose (120 mg·kg@*RESULTS@#Compared with the blank group, the average escape latency was prolonged (@*CONCLUSION@#Pretreatment of acupuncture could prevent and treat the learning-memory dysfunction in AD like rats, and its mechanism may be related to the inhibition of NLRP3 inflammatsome related protein and MG activation.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Électroacupuncture
/
Rat Sprague-Dawley
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Inflammasomes
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Maladie d'Alzheimer
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Protéine-3 de la famille des NLR contenant un domaine pyrine
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Hippocampe
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Zhongguo zhenjiu
Année:
2020
Type:
Article