Clinical Application of Circulating Tumor DNA in Diffuse Large B-Cell Lymphoma--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 638-642, 2021.
Article
Dans Zh
| WPRIM
| ID: wpr-880126
Responsable en Bibliothèque :
WPRO
ABSTRACT
Diffuse large B-cell lymphoma (DLBCL) as an aggressive lymphoma, there has not a good molecular marker to assess the therapeutic efficacy and prognosis of the disease. As compared with the traditional deteation method, it was found that the circulating tumor DNA (ctDNA) can be used as a non-invasive specific biomarker which can dynamically provide the information about the lymphoma. ctDNA in DLBCL can be obtained by dideoxy chain termination method combined with PCR, so as to detect genetic markers, targeted sequences of gene which is related to lymphoma; the digital PCR (dPCR) for lymphoma somatic mutations and the detection of abnormal methylation; ctDNA is closely related to the diagncsis, therapeutic efficiency and prognosis of DLBCL, thus ctDNA can be used for the early detection, mid-term and prognostic monitoring in DLBCL, which makes ctDNA have a broad clinical applied prospect.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pronostic
/
Marqueurs biologiques tumoraux
/
Réaction de polymérisation en chaîne
/
Lymphome B diffus à grandes cellules
/
ADN tumoral circulant
Type d'étude:
Prognostic_studies
/
Screening_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2021
Type:
Article