Relationship between IKZF3 Gene Single Nucleotide Polymorphisms and Childhood Acute Lymphoblastic Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 690-695, 2021.
Article
Dans Zh
| WPRIM
| ID: wpr-880134
Responsable en Bibliothèque :
WPRO
ABSTRACT
OBJECTIVE@#To investigate the relationship between single nucleotide polymorphisms (SNPs) of IKAROS family Zinc finger 3 (IKZF3) gene and the risk of acute lymphoblastic leukemia (ALL) in children.@*METHODS@#The peripheral blood samples from 286 children with ALL and 382 healthy children were collected and divided into ALL group and control group, respectively. The genotypes of IKZF3 gene at rs62066988 C > T and rs12946510 C > T were detected by quantitative PCR with TaqMan detection system, and their correlation with ALL was analyzed.@*RESULTS@#The distribution frequencies of CC, CT and TT genotypes at rs62066988 in ALL group were 58.39%, 37.06% and 4.55%, respectively, while those in control group were 69.19%, 27.68% and 3.13%, respectively. The distribution frequencies of CC, CT and TT genotypes at rs12946510 in ALL group were 58.16%, 34.75% and 7.09%, respectively, while those in control group were 55.76%, 37.43% and 6.81%, respectively. Compared with the control group, the distribution frequency of CT/TT genotype at rs62066988 was significantly increased in the ALL group (OR=1.59, 95%CI 1.16-2.19, P=0.004). However, there was no significant difference in the distribution of rs12946510 C > T polymorphism between ALL group and control group.@*CONCLUSION@#The CT/TT genotype of IKZF3 at the site of rs62066988 is associated with the increased risk of ALL in children.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Études cas-témoins
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Prédisposition génétique à une maladie
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Polymorphisme de nucléotide simple
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Allèles
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Facteur de transcription Ikaros
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Leucémie-lymphome lymphoblastique à précurseurs B et T
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Fréquence d'allèle
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Génotype
Type d'étude:
Observational_studies
/
Risk_factors_studies
Limites du sujet:
Child
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Humans
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2021
Type:
Article