Four new polyhydroxylated steroids from the South Sea sponge Plakortis sp / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
; (6): 844-849, 2020.
Article
de En
| WPRIM
| ID: wpr-881028
Bibliothèque responsable:
WPRO
ABSTRACT
Four new polyhydroxylated steroids plaksterols A-D (1-4), together with two known related steroids ergost-7,9(11),22-trien-3β,5α,6α-triol (5) and ergosta-6β-methoxy-7,22-diene-3β,5α-diol (6), were isolated from methanol extract of the South China Sea marine sponge Plakortis sp. Their structures were identified by spectroscopic analysis, including NMR, MS, and IR. The cytotoxicity of the polyhydroxylated steroids were evaluated, and compound 6 showed moderate inhibitory activities against K562, HL-60 and BEL-7402 cells.
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WPRIM
langue:
En
Texte intégral:
Chinese Journal of Natural Medicines (English Ed.)
Année:
2020
Type:
Article