Expression Pattern of Caspase 2 in Korean Gastric Cancers
Journal of the Korean Gastric Cancer Association
; : 38-43, 2003.
Article
de Ko
| WPRIM
| ID: wpr-88530
Bibliothèque responsable:
WPRO
ABSTRACT
PURPOSE: Caspase 2, a member of the family of ICE-like proteases, is activated by the Fas pathway and induces apoptosis by triggering the caspase cascade. The purpose of this study was to determine whether the expression pattern of caspase 2 might be associated with gastric cancer development and if so, to determine to which pathologic parameter it is linked. MATENRIALS AND METHODS: For the construction of the gastric cancer tissue microarray, 78 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression pattern of caspase 2 was examined on tissue microarray slides by using immunohistochemistry and was compared with pathologic parameters, including histologic type, depth of invasion, lymph node metastasis, and peritoneal dissemination. RESULTS: Caspase 2 was expressed on superficial and foveolar epithelial cells and lymphocytes in the gastric mucosa, mainly in cytoplasm. We found loss of caspase 2 expression in 41 (52.6%) of the 78 gastric cancer tissues. Statistically, histologic type and other pathologic parameters were not related with loss of caspase 2 expression. CONCLUSION: Our findings provide enough evidence that loss of caspase 2 expression may contribute to the development of Korean gastric cancer and that it might be one of the possible escape mechanisms from apoptosis in gastric cancer.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Peptide hydrolases
/
Tumeurs de l'estomac
/
Nations Unies
/
Immunohistochimie
/
Lymphocytes
/
Apoptose
/
Cytoplasme
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Cellules épithéliales
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Caspase-2
/
Muqueuse gastrique
Limites du sujet:
Humans
langue:
Ko
Texte intégral:
Journal of the Korean Gastric Cancer Association
Année:
2003
Type:
Article