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Research advances on the effect of ginsenoside Rg1 on angiogenesis and vascular protection / 药学学报
Yao Xue Xue Bao ; (12): 2146-2153, 2021.
Article de Zh | WPRIM | ID: wpr-887034
Bibliothèque responsable: WPRO
ABSTRACT
Ginsenoside Rg1 is one of the most important active components of the "king of herbs" Panax ginseng, which is an important angiogenic protective agent. The research results have shown that Rg1 has a wide range of cardiovascular pharmacological effects in vivo and in vitro, mainly through promoting the proliferation of smooth muscle cells, inhibiting endothelial cell aging, antioxidant stress, inhibiting inflammatory response, activating key factors of angiogenesis, improving vasodilation and other ways. Many miRNAs participate in the process of Rg1 promoting angiogenesis, mediate the regulation of the specific expression of downstream related targets to promote angiogenesis and vascular remodeling, and have the potential to become new clinical biomarkers and therapeutic targets. New preparation technologies and materials are used to make up for the weakness of Rg1's blood-brain barrier permeability, and further promote and enrich the clinical application of Rg1.
Mots clés
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Yao Xue Xue Bao Année: 2021 Type: Article
Texte intégral: 1 Indice: WPRIM langue: Zh Texte intégral: Yao Xue Xue Bao Année: 2021 Type: Article