Research Status of TPO/c-MPL Signaling Pathway in Acute Myeloid Leukemia--Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1351-1354, 2021.
Article
de Zh
| WPRIM
| ID: wpr-888565
Bibliothèque responsable:
WPRO
ABSTRACT
Thrombopoietin (TPO) can activate hematopoietic cell proliferation by its receptor c-MPL mediated downstream pathways and induce the generation of megakaryocyte. In recent years, domestic and foreign researches have confirmed that TPO/ c-MPL pathway also plays an important role in the self-renewal and quiescence of leukemia stem cell, and its expression in acute myeloid leukemia (AML) also indicates the chemotherapy resistance and poor prognosis. In this article, the research progress of the roles of TPO/c-MPL pathway in chemotherapy resistance, prognosis of AML patients, and the application of TPO/ c-MPL receptor agonists in AML were summarized briefly.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Thrombopoïétine
/
Leucémie aigüe myéloïde
/
Transduction du signal
/
Protéines proto-oncogènes
/
Récepteurs aux cytokines
/
Récepteurs à la thrombopoïétine
/
Protéines tumorales
Type d'étude:
Prognostic_studies
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Journal of Experimental Hematology
Année:
2021
Type:
Article