Your browser doesn't support javascript.
loading
Targeted inhibition of GRK2 kinase domain by CP-25 to reverse fibroblast-like synoviocytes dysfunction and improve collagen-induced arthritis in rats
Acta Pharmaceutica Sinica B ; (6): 1835-1852, 2021.
Article de En | WPRIM | ID: wpr-888837
Bibliothèque responsable: WPRO
ABSTRACT
Rheumatoid arthritis (RA) is an autoimmune disease and is mainly characterized by abnormal proliferation of fibroblast-like synoviocytes (FLS). The up-regulated cellular membrane expression of G protein coupled receptor kinase 2 (GRK2) of FLS plays a critical role in RA progression, the increase of GRK2 translocation activity promotes dysfunctional prostaglandin E4 receptor (EP4) signaling and FLS abnormal proliferation. Recently, although our group found that paeoniflorin-6'-
Mots clés
Texte intégral: 1 Indice: WPRIM langue: En Texte intégral: Acta Pharmaceutica Sinica B Année: 2021 Type: Article
Texte intégral: 1 Indice: WPRIM langue: En Texte intégral: Acta Pharmaceutica Sinica B Année: 2021 Type: Article