Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation
Acta Pharmaceutica Sinica B
; (6): 2880-2899, 2021.
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| ID: wpr-888892
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ABSTRACT
Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative colitis. Although targeting NLRP3 inflammasome has been considered to be a potential therapy, the underlying mechanism through which pathway the intestinal inflammation is modulated remains controversial. By focusing on the flavonoid lonicerin, one of the most abundant constituents existed in a long historical anti-inflammatory and anti-infectious herb
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WPRIM
langue:
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Texte intégral:
Acta Pharmaceutica Sinica B
Année:
2021
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Article